PLANNING, SYNTHESIS AND CHARACTERIZATION OF N-(2,4-DINITROPHENYL)HISTIDINETHIOSEMICARBAZIDES AS POTENTIAL ANTITUMOUR AGENTS
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Once amino acids are a structural leitmotiv in the evolution, their incorporation in synthetic compounds represents a promising strategy toward the development of new antitumour drugs. A library of histidinethiosemicarbazide derivatives was prepared, and characterised through spectroscopic methods. Their biological activity are now under investigation, and the initial perspectives point to positive outcomes. ◀The planning, synthesis and antitumoral evaluation of Nα-(2,4-dinitrophenyl)-histidinethiosemicarbazide have been one field of research effort at the SintM ▶" "modalidade" => "Pôster (PO)" "area_tematica" => "QUÍMICA" "palavra_chave" => "2,4-DNP AMINO ACIDS, THIOSEMICARBAZIDES, ANTITUMORAL ACTIVITY" "idioma" => "Inglês" "arquivo" => "TRABALHO_EV081_MD4_SA41_ID288_11072017140617.pdf" "created_at" => "2020-05-28 15:53:37" "updated_at" => "2020-06-10 12:56:42" "ativo" => 1 "autor_nome" => "EVERTON FIDELIS DO NASCIMENTO" "autor_nome_curto" => "EVERTON FIDELIS" "autor_email" => "everton.fidelis@hotmail.c" "autor_ies" => "UNIVERSIDADE FEDERAL DE PERNAMBUCO (UFPE)" "autor_imagem" => "" "edicao_url" => "anais-iii-join---edicao-brasil" "edicao_nome" => "Anais III JOIN / Edição Brasil" "edicao_evento" => "III Encontro de Jovens Investigadores - Edição Brasil" "edicao_ano" => 2017 "edicao_pasta" => "anais/join/2017" "edicao_logo" => "5e4a1cc2ad894_17022020015530.jpg" "edicao_capa" => "5f186f10b9555_22072020135336.jpg" "data_publicacao" => null "edicao_publicada_em" => "2017-10-12 00:00:00" "publicacao_id" => 47 "publicacao_nome" => "Anais JOIN" "publicacao_codigo" => "2594-8318" "tipo_codigo_id" => 1 "tipo_codigo_nome" => "ISSN" "tipo_publicacao_id" => 1 "tipo_publicacao_nome" => "ANAIS de Evento" ] #original: array:35 [▶ "id" => 50071 "edicao_id" => 73 "trabalho_id" => 86 "inscrito_id" => 288 "titulo" => "PLANNING, SYNTHESIS AND CHARACTERIZATION OF N-(2,4-DINITROPHENYL)HISTIDINETHIOSEMICARBAZIDES AS POTENTIAL ANTITUMOUR AGENTS" "resumo" => "The planning, synthesis and antitumoral evaluation of Nα-(2,4-dinitrophenyl)-histidinethiosemicarbazide have been one field of research effort at the SintMed®. 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