PLANNING, SYNTHESIS AND CHARACTERIZATION OF N-(2,4-DINITROPHENYL)HISTIDINETHIOSEMICARBAZIDES AS POTENTIAL ANTITUMOUR AGENTS
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App\Base\Administrativo\Model\Artigo {#1843 // app/Providers/../Base/Publico/Artigo/resources/show_includes/info_artigo.blade.php #connection: "mysql" +table: "artigo" #primaryKey: "id" #keyType: "int" +incrementing: true #with: [] #withCount: [] +preventsLazyLoading: false #perPage: 15 +exists: true +wasRecentlyCreated: false #escapeWhenCastingToString: false #attributes: array:35 [ "id" => 50071 "edicao_id" => 73 "trabalho_id" => 86 "inscrito_id" => 288 "titulo" => "PLANNING, SYNTHESIS AND CHARACTERIZATION OF N-(2,4-DINITROPHENYL)HISTIDINETHIOSEMICARBAZIDES AS POTENTIAL ANTITUMOUR AGENTS" "resumo" => "The planning, synthesis and antitumoral evaluation of Nα-(2,4-dinitrophenyl)-histidinethiosemicarbazide have been one field of research effort at the SintMed®. Exploiting the association between an amino acid scaffold and the thiosemicarbazide moiety, a new series of compounds was designed, and synthesised in order to investigate their biological activity. Once amino acids are a structural leitmotiv in the evolution, their incorporation in synthetic compounds represents a promising strategy toward the development of new antitumour drugs. A library of histidinethiosemicarbazide derivatives was prepared, and characterised through spectroscopic methods. Their biological activity are now under investigation, and the initial perspectives point to positive outcomes." 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Exploiting the association between an amino acid scaffold and the thiosemicarbazide moiety, a new series of compounds was designed, and synthesised in order to investigate their biological activity. Once amino acids are a structural leitmotiv in the evolution, their incorporation in synthetic compounds represents a promising strategy toward the development of new antitumour drugs. A library of histidinethiosemicarbazide derivatives was prepared, and characterised through spectroscopic methods. Their biological activity are now under investigation, and the initial perspectives point to positive outcomes." 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